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Art. -Nr.: HY-182511

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IUN-00433

IUN-00433 (Compound 36) is a selective positive allosteric modulator of α4β1δ-type GABA_A receptors, with an EC₅₀ of 0.060 μM. IUN-00433 is applicable to research related to neurological disorders.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2188230-70-6
Formel: C₁₈H₁₁BrClN₃OS
Molecular Weight:432.72

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IUN-00433 Chemical Structure

CAS. Nr.: 2188230-70-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

α4β1δ GABA_A

0.060 μM (EC₅₀)

In Vitro

IUN-00433 exerts positive allosteric regulatory activity on α4β1δ, with an EC₅₀ of 0.060 μM, which is 16-fold more potent than DS2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2188230-70-6
Molecular Weight 432.72
Formel C₁₈H₁₁BrClN₃OS
SMILES

O=C(C1=CC=C(C=C1)Cl)NC2=C(C3=CC=CS3)N=C4C=CC(Br)=CN42
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Rostrup F, et al. Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors. J Med Chem. 2021;64(8):4730-4743. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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