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Art. -Nr.: HY-111051

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JN403

JN403 is an orally active and selective α7 nicotinic acetylcholine receptor agonist. JN403 can be used in the study of central nervous system disorders.

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CAS. Nr.: 942606-12-4
Formel: C₁₆H₂₁FN₂O₂
Molecular Weight:292.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JN403 Chemical Structure

CAS. Nr.: 942606-12-4

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

JN403 is an orally active and selective α7 nicotinic acetylcholine receptor agonist. JN403 can be used in the study of central nervous system disorders^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
GH3	EC₅₀	100 nM Compound: 30, JN403	Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assay Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assay	[PMID: 21919481]
Oocyte	EC₅₀	2 μM Compound: 30, JN403	Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward current Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward current	[PMID: 21919481]

Chemical Information

CAS. Nr. 942606-12-4
Molecular Weight 292.35
Formel C₁₆H₂₁FN₂O₂
SMILES

C[C@@H](C1=C(C=CC=C1)F)OC(N[C@H]2C3CCN(CC3)C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Feuerbach D, et al. The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology. 2009 Jan;56(1):254-63.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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