MDX-1342
MDX-1342 is a fully human monoclonal antibody (HuMAb) of targeting CD19-membrane receptor. MDX-1342 can specifically bind to human CD19 antigen with high affinity and has antibody-dependent cellular cytotoxicity (ADCC) effect. MDX-1342 can be used for the research of B-lymphocyte malignancies and autoimmune.
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- CAS. Nr.: 1646327-65-2
- Formel: D
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
EC50 for binding activity: 0.34 μg/mL(Ramos cells); 0.47 μg/mL(Raji cells); 0.74 μg/mL(ARH-77 cells); 0.37 μg/mL(FcyRIIIa-Val158 transfected cells); 1.18 μg/mL(FcyRIIIaPhe158 transfected cells)[1]
In Vitro
MDX-1342 (0-100 μg/mL; 30 min) shows binding activity for Ramos, Raji, and ARH-77 cells with EC50 values of 0.34, 0.47, and 0.74 μg/mL, respectively[1].
MDX-1342 (0-100 μg/mL; 30 min) shows binding activity for FcyRIIIa-Val158 and FcyRIIIaPhe158 transfected cells with EC50 values of 0.37 and 1.18 μg/mL, respectively[1].
MDX-1342 (0-100 μg/mL) has robust antibody-dependent cellular cytotoxicity (ADCC) with an average EC50 value of 0.01-0.02 ug/mL[1].
MDX-1342 (0-100 μg/mL) mediates dose-dependent phagocytosis of ARH-77 cells by macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human CD19-transfected CHO cells
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Concentration:0-100 μg/mL
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Incubation Time:30 min
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Result:Exhibited increased affinity for FcyRIlla-Phe158 and FcyRIlla-Val158 receptors.
In Vivo
MDX-1342 (i.v.; 0.1 or 1 mg/kg; single) has low nanomolar binding to cynomolgus monkey CD19, increases affinity for cynomolgus monkey FcyRllla and reveals potent B-cell depletion in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:cynomolgus monkey[1]
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Dosage:0.1 or 1 mg/kg
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Administration:i.v., single
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Result:Showed B-cell depletion in the cynomolgus monkey.
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Animal Model:Ramos systemic tumor xenograft model(SCID mice)[1]
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Dosage:0.03, 0.3, 3 and 30 mg/kg
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Administration:i.v., 200 μL
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Result:Showed dose-dependent improvement in survival.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Anwendung
ELISA, FACS, Functional assay
Chemical Information
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CAS. Nr. 1646327-65-2
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Formel D
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SMILES
[2H][M][X1342]
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MDX-1342 Related Classifications
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