ML2006a4
ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (Mpro) with IC50 in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2943213-62-3
- Formel: C30H44F3N5O6
- Molecular Weight:627.70
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
ML2006a4 (40 mg/kg, p.o., twice a day for 4 days) ameliorates the SARS-CoV-2 infection, exhibits viral inhibitory and lung protective efficacy in BALB/c mice without significant toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SARS-CoV-2 MA10 infected BALB/c mice[1]
-
Dosage:40 mg/kg
-
Administration:p.o., twice a day for 4 days
-
Result:Reduced inflammation and respioratory epithelial injury, improved epithelial regeneration and the survival rates with minimal weight loss.
Chemical Information
-
CAS. Nr. 2943213-62-3
-
Molecular Weight 627.70
-
Formel C30H44F3N5O6
-
SMILES
O=C([C@@H]1[C@@]2([H])C(C)(C)[C@@]2([H])CN1C([C@@H](NC(C(F)(F)F)=O)C(C)(C)C)=O)N[C@H](C(C(N3CC(C)(C)C3)=O)=O)C[C@H]4C(NCCC4)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz