NF023 hexasodium
Based on 2 publication(s) in Google Scholar
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.
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- Reinheit: 99.99%
- CAS. Nr.: 104869-31-0
- Formel: C35H20N4Na6O21S6
- Molecular Weight:1162.88
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NF023 hexasodium
MoreAlle P2X Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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p2x1 Receptor |
NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC50 value of approximately 300 nM)[2].
NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1.190.2 μM)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 104869-31-0
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Appearance Solid
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Molecular Weight 1162.88
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Formel C35H20N4Na6O21S6
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Color White to off-white
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SMILES
O=C(C1=CC(NC(NC2=CC(C(NC(C(C([S](=O)(O[Na])=O)=C3)=C4C=C3[S](=O)(O[Na])=O)=CC=C4[S](=O)(O[Na])=O)=O)=CC=C2)=O)=CC=C1)NC(C(C([S](=O)(O[Na])=O)=C5)=C6C=C5[S](=O)(O[Na])=O)=CC=C6[S](=O)(O[Na])=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Antiviral Res
2026 Jun 22:252:106470. PMID: 42331291 -
J Virol
Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor. [Abstract]2024 Oct 30:e0119324. PMID: 39475276
Lösungsmittel & Löslichkeit
H2O : ≥ 116.3 mg/mL (100.01 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan;38(1):141-9. [Content Brief]
[2]. M Freissmuth, et al. Suramin Analogues as Subtype-Selective G Protein Inhibitors. Mol Pharmacol. 1996 Apr;49(4):602-11. [Content Brief]
[3]. G Lambrecht, et al. Agonists and Antagonists Acting at P2X Receptors: Selectivity Profiles and Functional Implications. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):340-50. [Content Brief]
[4]. M Silva-Ramos, et al. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders. J Pharmacol Exp Ther. 2020 Jan;372(1):63-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8599 mL | 4.2997 mL | 8.5993 mL | 21.4983 mL |
| 5 mM | 0.1720 mL | 0.8599 mL | 1.7199 mL | 4.2997 mL | |
| 10 mM | 0.0860 mL | 0.4300 mL | 0.8599 mL | 2.1498 mL | |
| 15 mM | 0.0573 mL | 0.2866 mL | 0.5733 mL | 1.4332 mL | |
| 20 mM | 0.0430 mL | 0.2150 mL | 0.4300 mL | 1.0749 mL | |
| 25 mM | 0.0344 mL | 0.1720 mL | 0.3440 mL | 0.8599 mL | |
| 30 mM | 0.0287 mL | 0.1433 mL | 0.2866 mL | 0.7166 mL | |
| 40 mM | 0.0215 mL | 0.1075 mL | 0.2150 mL | 0.5375 mL | |
| 50 mM | 0.0172 mL | 0.0860 mL | 0.1720 mL | 0.4300 mL | |
| 60 mM | 0.0143 mL | 0.0717 mL | 0.1433 mL | 0.3583 mL | |
| 80 mM | 0.0107 mL | 0.0537 mL | 0.1075 mL | 0.2687 mL | |
| 100 mM | 0.0086 mL | 0.0430 mL | 0.0860 mL | 0.2150 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NF023 hexasodium Related Classifications
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