O-GlcNAcase-IN-2
O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C22H26N4OS
- Molecular Weight:394.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
IC50: 4.93 nM (OGA)[1]
Chemical Information
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Molecular Weight 394.53
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Formel C22H26N4OS
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SMILES
CC(NC(S1)=NC=C1CN(CC2)CCC2C#CC3=CC(CCCN4)=C4C=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
O-GlcNAcase-IN-2 Related Classifications
HY-161953 Related Classifications
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