PhAc-ALGP-Dox
PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells.
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- CAS. Nr.: 1616592-31-4
- Formel: C45H58N5O19P
- Molecular Weight:1003.94
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
PhAc-ALGP-Dox is sequentially activated via a tumor-specific two-step cleavage, initiated by extracellular THOP1 and further processed by FAPα/DPP4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1616592-31-4
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Molecular Weight 1003.94
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Formel C45H58N5O19P
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Sequence
{Phosphonoacetyl}-Ala-Leu-Gly-Pro-{Dox}
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Sequence Shortening
{Phosphonoacetyl}-ALGP-{Dox}
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PhAc-ALGP-Dox Related Classifications
HY-P10760 Related Classifications
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