Phaeocaulisin M
Phaeocaulisin M is a guaiane-type sesquiterpene containing a novel 1,2-dioxolane-3-ol structure. Phaeocaulisin M inhibits LPS (HY-D1056)-induced nitric oxide (NO) production in RAW 264.7 macrophages with an IC50 of 6.05 μM, and shows no significant cytotoxicity at the effective concentrations for inhibiting NO production. Phaeocaulisin M is found in the rhizomes of Curcuma phaeocaulis and can be used for research related to inflammatory responses.
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- CAS. Nr.: 1966155-64-5
- Formel: C15H24O5
- Molecular Weight:284.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
6.05 μM
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Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages incubated for 24 h, measured by Griess reagent assay of nitrite concentration in cell supernatant.
Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages incubated for 24 h, measured by Griess reagent assay of nitrite concentration in cell supernatant.
|
10286020.2015.1046449 |
In Vitro
Phaeocaulisin M (compound 3) (1 μg/mL LPS; 24 h) inhibits LPS-induced NO production in RAW 264.7 macrophages with an IC50 of 6.05 μM and exhibits no significant cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1966155-64-5
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Molecular Weight 284.35
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Formel C15H24O5
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SMILES
OC12C(C(C)(OO2)C)=C[C@@]3([H])[C@](CC[C@@]3(O)C)([H])[C@@](O)(C1)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)