Phenanthridine
Phenanthridine is an aldehyde oxidase 1 (AOX1) substrate, with oxidation by hAOX1 yielding phenanthridone when molecular oxygen, ferricyanide, or dichlorophenolindophenol serves as electron acceptor.
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- CAS. Nr.: 229-87-8
- Formel: C13H9N
- Molecular Weight:179.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
AOX1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
50 μM
Compound: 5b
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Cytotoxicity against human A549 cells incubated for 24 to 48 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 24 to 48 hrs by MTT assay
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[PMID: 40147342] |
In Vitro
Phenanthridine (40 μM) is used as substrate to show that in vitro chemical sulfuration increases the specific activity of hAOX1-WT, co-hAOX1, and hAOX1-S1271L by ~10-fold, with hAOX1-WT reaching 1516.7 mU/mg, co-hAOX1 reaching 1459.1 mU/mg, and hAOX1-S1271L reaching 1132.1 mU/mg after sulfuration[1].
Phenanthridine is used as substrate to show that codon-optimized hAOX1-WT has a pH optimum of ~8.0, while hAOX1-S1271L has a slightly shifted pH optimum of ~8.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 229-87-8
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Appearance Solid
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Molecular Weight 179.22
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Formel C13H9N
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Color White to off-white
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SMILES
N1=CC2=CC=CC=C2C3=CC=CC=C13
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Phenanthridine Related Classifications
HY-W142745 Related Classifications
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