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Art. -Nr.: HY-N20751

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Planispine A

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CAS. Nr.: 1202761-42-9
Formel: C₂₅H₃₀O₆
Molecular Weight:426.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

Planispine A Chemical Structure

CAS. Nr.: 1202761-42-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- In Vitro
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Biologische Aktivität

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	21.38 μM	Antiproliferative activity against human HeLa cancer cells assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A. Antiproliferative activity against human HeLa cancer cells assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A.	36364114
HeLa	IC50	3.9 μM	Antiproliferative activity against human HeLa cancer cells in combination with 25 μM cisplatin, assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A. Antiproliferative activity against human HeLa cancer cells in combination with 25 μM cisplatin, assessed as reduction in cell viability using CellTiter 96 AQueous One Solution assay with 16 h pre-incubation of planispine A.	36364114

In Vitro

Anti-cancerApoptosisCell Cycle Regulation

Anti-cancer

Planispine A (2-40 μM; 16 h) inhibits the proliferation of HeLa cells in a dose-dependent manner, with an IC₅₀ of 21.38 μM; meanwhile, this compound synergistically enhances the antiproliferative effect of Cisplatin (HY-17394). When combined with 25 μM Planispine A, the IC₅₀ of Cisplatin alone decreases to 3.9 μM^[1].
Planispine A (5-10 μM; 16 h) inhibits the Fanconi anemia pathway in HeLa cells by reducing cisplatin-induced FANCD2 foci formation and monoubiquitination modification, with monoubiquitination completely blocked at a concentration of 10 μM^[1].

Anti-cancer

Apoptosis

Planispine A (5-10 μM; 16-64 h) enhances cisplatin-induced apoptotic death of HeLa cells via a caspase-dependent mechanism, which is evidenced by increased formation of apoptotic nuclei and enhanced cleavage of caspase-3 and PARP^[1].

Anti-cancer

Cell Cycle Regulation

Combination treatment with Planispine A (3-10 μM) and cisplatin induces S-phase cell cycle arrest in HeLa cells and reduces the expression of cyclin D1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1202761-42-9
Molecular Weight 426.50
Formel C₂₅H₃₀O₆
SMILES

COC1=C(OC/C=C(C)/C)C=CC([C@H]2[C@@]3([H])[C@](CO2)([H])[C@@H](C4=CC(OC)=C(C=C4)O)OC3)=C1
Structure Classification
- Phenols
- Monophenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.