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Art. -Nr.: HY-187974

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PNU-37883

PNU-37883 is a selective vascular K_ATP channel blocker. PNU-37883 prevents K⁺ efflux/hyperpolarization, inhibits K_ATP-mediated vasodilation, and does not alter vascular tone when used alone. PNU-37883 can be used in research on hypertension and viral infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 122252-09-9
Formel: C₂₁H₃₅N₃O
Molecular Weight:345.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (290 KB)

PNU-37883 Chemical Structure

CAS. Nr.: 122252-09-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Local Vascular RegulationViral Infection

Local Vascular Regulation

PNU-37883 (0.1-10 nM) attenuates Agmatine (HY-WAA0304)-induced relaxation of SHR aortic rings precontracted with phenylephrine or KCl, supporting its blocking effect on vascular K_ATP channels^[1].
PNU-37883 (10 μM; 30 min) eliminates [Ca²⁺]₀-induced vasodilation and reveals contraction in capsaicin (HY-10448)-pretreated rat first-order mesenteric arteries^[2].
PNU-37883 (10 µM) inhibits Pinacidil (HY-14290)- and Adenosine (HY-B0228)-evoked K_ATP currents in isolated mouse brain capillary endothelial cells^[3].
PNU-37883 reverses Pinacidil-induced K_ATP currents in freshly isolated mouse brain capillary endothelial cells^[4].
PNU-37883 inhibits Adenosine-induced K_ATP currents in mouse brain capillary endothelial cells and pericytes^[4].

Viral Infection

PNU-37883 inhibits EBOV-ZsG infection in Huh7 cells with an EC₅₀ of 1.47 μM (SI >34.01), but shows no activity in A549 cells and has lower potency in HeLa and Vero E6 cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS. Nr. 122252-09-9
Molecular Weight 345.52
Formel C₂₁H₃₅N₃O
SMILES

C(/NC1CCCCC1)(N2CCOCC2)=N\C34CC5CC(C4)CC(C3)C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mar GY, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. International journal of experimental pathology. 2013 Feb;94(1):17-24. [Content Brief]

[2]. Carlton-Carew SRE, et al. Stimulation of the calcium-sensing receptor induces relaxations through CGRP and NK1 receptor-mediated pathways in male rat mesenteric arteries. Physiological reports. 2024 Jun;12(12):e16125.

[3]. Sancho M, et al. Electro-Metabolic Sensing Through Capillary ATP-Sensitive K⁺ Channels and Adenosine to Control Cerebral Blood Flow. bioRxiv. 2021 Mar 13.

[4]. Sancho M, et al. Adenosine signaling activates ATP-sensitive K channels in endothelial cells and pericytes in CNS capillaries. Science signaling. 2022 Mar 29;15(727):eabl5405.

[5]. Kelly JA, et al. Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis. Antiviral research. 2025 Jun;238:106167.

[6]. Ekman M, et al. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle. European journal of pharmacology. 2012 May 15;683(1-3):238-45.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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