AMPK
AMPK (AMP-activated protein kinase) is a heterotrimeric serine/threonine kinase composed of catalytic α and regulatory β and γ subunits that functions as the principal cellular energy sensor. A rising AMP:ATP ratio, sensed by the γ subunit, allows the upstream kinases LKB1 and CaMKKβ to activate AMPK, which then phosphorylates ACC, TSC2 and Raptor to switch on catabolism while suppressing anabolic processes and mTORC1 signaling. Pharmacological activation by metformin, salicylate and direct AMPK activators places the complex at the center of diabetes, obesity and cancer metabolism research.
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AMPK Recombinant Proteins (7)
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Inhibitors & Agonists (501)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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