CLK2
CLK2 encodes a broadly expressed CDC-like kinase that pairs an N-terminal RS-rich region with a dual-specificity catalytic domain. As with its paralogs, autophosphorylation of the activation-segment tyrosine licenses serine/threonine activity directed at the RS domains of SR splicing factors, positioning CLK2 within the nuclear speckle machinery that governs alternative splicing and mRNA maturation. Knockdown experiments link CLK2 to cell-cycle progression and to the survival of proliferating cells, and its activity is sensitive to the same ATP-competitive chemotypes that inhibit CLK1 and CLK3. The recombinant kinase is valuable for comparative splicing studies and for defining compound selectivity across the CLK family.
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CLK2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
