IgG2B
Within mouse immunoglobulin G, IgG2b is the heavy-chain subclass notable for efficient classical-pathway complement activation together with engagement of activating Fc gamma receptors, activities that support opsonization, ADCC, and complement-mediated lysis. Mouse IgG2b antibodies are frequently chosen for in vivo functional studies and depletion protocols in which complement-dependent cytotoxicity is desired, and the subclass commonly serves as an isotype-matched control in flow cytometry and immunohistochemistry. In antibody engineering, murine IgG2b Fc sequences also appear in chimeric and humanized constructs used to compare effector mechanisms across species-specific Fc formats in preclinical models.
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IgG2B Recombinant Proteins (2)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
