PLK2
PLK2, also called SNK, contrasts with its mitotic paralog PLK1 by acting earlier in the cell cycle and in post-mitotic neurons. Transcriptionally induced in G1 and by serum stimulation, PLK2 supports centriole duplication together with PLK4 and restrains unscheduled proliferation, giving it tumor-suppressive traits in several contexts. In the brain, PLK2 homeostatically phosphorylates α-synuclein at Ser129, limiting its toxic aggregation, and it contributes to synaptic scaling and neuronal survival after stress. Reduced PLK2 activity has been linked to α-synucleinopathies and to some cancers. Recombinant PLK2 enables studies of centriole biology, α-synuclein regulation, and PLK-family redundancy.
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PLK2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
