New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria

  • Molecules. 2016 Oct 17;21(10):1385. doi: 10.3390/molecules21101385.
Jih-Jung Chen  1  2 ,  Tung-Han Tsai  3 ,  Hsiang-Ruei Liao  4 ,  Li-Chai Chen  5  6 ,  Yueh-Hsiung Kuo  7  8 ,  Ping-Jyun Sung  9 ,  Chun-Lin Chen  10 ,  Chun-Sheng Wei  11
Affiliations
  • 1. Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. [email protected].
  • 2. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. [email protected].
  • 3. Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. [email protected].
  • 4. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. [email protected].
  • 5. Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. [email protected].
  • 6. Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan. [email protected].
  • 7. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. [email protected].
  • 8. Department of Biotechnology, Asia University, Taichung 413, Taiwan. [email protected].
  • 9. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. [email protected].
  • 10. Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. [email protected].
  • 11. Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan. [email protected].
PMID: 27763530 DOI: 10.3390/molecules21101385
Abstract

Two new sesquiterpenoids-13-hydroxycurzerenone (1) and 1-oxocurzerenone (2)-have been isolated from the rhizomes of Curcuma zedoaria, together with 13 known compounds (3-15). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-hydroxycurzerenone (1), 1-oxocurzerenone (2), curzerenone (3), germacrone (4), curcolone (5), procurcumenol (6), ermanin (7), curcumin (8), and a mixture of stigmast-4-en-3,6-dione (12) and stigmasta-4,22-dien-3,6-dione (13) exhibited inhibition (with inhibition % in the range of 21.28%-67.58%) against collagen-induced platelet aggregation at 100 μM. Compounds 1, 5, 7, 8, and the mixture of 12 and 13 inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%-95.36%.

Keywords
Curcuma zedoaria; Zingiberaceae; anti-platelet aggregation; rhizomes; sesquiterpenoids.
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