country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-117021

Copy Link Print Information

RO 5073012

RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a K_i of 6 nM for hTAAR1 and EC₅₀ values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1020814-70-3
Formel: C₁₃H₁₆ClN₃
Molecular Weight:249.74

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RO 5073012 Chemical Structure

CAS. Nr.: 1020814-70-3

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

hTAAR1

6 nM (Ki)

mTAAR1

23 nM (EC₅₀)

rTAAR1

25 nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	23 nM Compound: 24, Ro-5073012	Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]
HEK293	EC₅₀	23 nM Compound: 24, Ro-5073012	Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]
HEK293	EC₅₀	25 nM Compound: 24, Ro-5073012	Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]

Chemical Information

CAS. Nr. 1020814-70-3
Molecular Weight 249.74
Formel C₁₃H₁₆ClN₃
SMILES

CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Galley G, et al. Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen