Sepetaprost
Sepetaprost (ONO-9054) is a dual agonist of the prostaglandin E3 receptor and prostaglandin F receptor. Sepetaprost reduces intraocular pressure in animal models. Sepetaprost is applicable for research on ocular hypertension and open-angle glaucoma.
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- CAS. Nr.: 1262873-06-2
- Formel: C26H36F2O6
- Molecular Weight:482.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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EP3 |
FP Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male cynomolgus monkeys[2]
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Dosage:0.002%
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Administration:topical ocular instillation; single dose
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Result:Significantly reduced IOP at 8, 10, 12, 26, and 28 h post-administration.
Showed consistently greater IOP-lowering effect than latanoprost at all measured time points.\nSignificantly enhanced outflow facility compared to vehicle.
Induced significant IOP reduction from baseline at 8, 24, and 26 h (IOP change from baseline: -1.3 mmHg at 8 h, -1.7 mmHg at 24 h, -1.4 mmHg at 26 h).
Had its IOP-lowering effect significantly attenuated at 26 h by pretreatment with an EP3 antagonist, with no significant differences observed at 8 or 24 h.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1262873-06-2
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Molecular Weight 482.56
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Formel C26H36F2O6
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SMILES
O=C(OC(C)C)CCC[C@H]1CC[C@@]([C@@H](/C=C/[C@@H](O)COC2=CC(F)=CC=C2F)[C@H](O)C3)([H])[C@@]3([H])OC1
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Synonyms
ONO-9054
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Suto F, et al. A Novel Dual Agonist of EP3 and FP Receptors for OAG and OHT: Safety, Pharmacokinetics, and Pharmacodynamics of ONO-9054 in Healthy Volunteers. Invest Ophthalmol Vis Sci. 2015;56(13):7963-7970. [Content Brief]
[2]. Maki K, et al. The Role of EP3 Agonism in Intraocular Pressure-Lowering by Sepetaprost, a Novel Dual Agonist of FP and EP3 Receptors, in Monkeys. J Ocul Pharmacol Ther. 2026;42(3):172-178. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sepetaprost Related Classifications
HY-128538 Related Classifications
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