TAS05567

When Ramos cells (human B lymphoma cells) are pretreated with TAS05567 prior to BCR cross-linking by exposure to anti-IgM, there is marked inhibition of the phosphorylation of BLNK, an adaptor protein phosphorylated by activated Syk. The IC₅₀ of TAS05567 for suppressing induction of BLNK phosphorylation by anti-IgM is 1.8 nM. TAS05567 also inhibits PLCγ2 (IC₅₀ of 23 nM) and Erk1/2 (IC₅₀ of 9.8 nM), after stimulation of Ramos cells with anti-IgM^[1].
TAS05567 shows concentration-dependent inhibition of TNF-α production by THP-1 cells stimulated with IgG^[1].
TAS05567 suppresses both calcium flux (IC₅₀ of 27 nM) and histamine release (IC₅₀ of 13 nM) induced by cross-linking of FcεRI with IgE and antigen^[1].
TAS05567 inhibits the formation of mature osteoclasts in a concentration-dependent manner, and osteoclast differentiation is completely suppressed at 30 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.