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Art. -Nr.: HY-183945

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WO-459

WO-459 is a potent Gpr52 agonist. WO-459 induces dose-dependent elevation of intracellular cAMP in cells expressing Gpr52. WO-459 can be used for the research of Huntington’s disease and psychotic disorders.

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CAS. Nr.: 1313195-84-4
Formel: C₂₃H₂₀F₃N₃O₂S
Molecular Weight:459.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

WO-459 Chemical Structure

CAS. Nr.: 1313195-84-4

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

WO-459 (Compound 12) (30 min) potently activates human GPR52 expressed in CHO cells with an EC₅₀ of 5.7 nM and an E_max of 102%^[1].
WO-459 (1 pM-10 μM) potently activates human Gpr52 in HEK293/hGpr52 cells with an EC₅₀ of 6 nM, increasing intracellular cAMP levels in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1313195-84-4
Molecular Weight 459.48
Formel C₂₃H₂₀F₃N₃O₂S
SMILES

O=C(C1=CN(C2=CC=CC3=C2SC(CC4=CC=CC(C(F)(F)F)=C4)=C3)N=C1C)NCCO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nakahata T, et al. Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists. Bioorg Med Chem. 2018 May 1;26(8):1598-1608. [Content Brief]

[2]. Song H, et al. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Brain. 2018;141(6):1782-1798. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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