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Art. -Nr.: HY-184281

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XAT-14

XAT-14 is a Furanocoumarin derivative. XAT-14 competes with agonists to bind to the active pocket of MRGPRX2, inhibiting calcium influx and mast cell degranulation. XAT-14 suppresses the release of histamine, IL-8 and MCP-1 induced by Compound 48/80 (HY-115768). XAT-14 inhibits local allergic inflammation. XAT-14 can be used for the research of pseudo-allergic diseases.

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CAS. Nr.: 3107904-59-3
Formel: C₂₁H₁₈O₅
Molecular Weight:350.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

XAT-14 Chemical Structure

CAS. Nr.: 3107904-59-3

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Beschreibung

IC₅₀ & Target^[1]

IL-8

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

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In Vitro

XAT-14 (100 μM) shows no cytotoxicity in LAD2 cells^[1].
XAT-14 (25-100 μM) potently inhibits Compound 48/80-induced β-hexosaminidase release in LAD2 cells, with an IC₅₀ of 22.95 μM, and exhibits superior efficacy to Imperatorin (HY-N0285)^[1].
XAT-14 (25-100 μM) dose-dependently inhibits Compound 48/80-induced release of histamine, IL-8 and MCP-1 in LAD2 cells^[1].
XAT-14 (25-100 μM) inhibits Compound 48/80-induced calcium influx in MRGPRX2-HEK293 cells in a dose-dependent manner, indicating that its effect is mediated through the MRGPRX2 signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XAT-14 (4-16 mg/kg) reduces the degree of hindlimb swelling and Evans blue extravasation induced by C48/80 in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3107904-59-3
Molecular Weight 350.36
Formel C₂₁H₁₈O₅
SMILES

O=C1OC2=C(OCCCOCC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yang W, et al. Furanocoumarin derivatives inhibit MRGPRX2-mediated pseudo-allergy. Bioorganic & medicinal chemistry letters. 2026 Jun;135:130589. [Content Brief]

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vivo
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XAT-14

High-Throughput Bioactive Compound Library

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XAT-14 Related Classifications

HY-184281 Related Classifications