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Art. -Nr.: HY-P99058

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Biologically Validated

Zolbetuximab

Name: Zolbetuximab
Brand: MedChemExpress
SKU: HY-P99058
Price: 320.00 USD
Availability: InStock
Rating: 5 (4 reviews)

(Synonyms: IMAB362; Claudiximab; GC-182)

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.03%
CAS. Nr.: 1496553-00-4
Molecular Weight:147.09 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zolbetuximab Chemical Structure

CAS. Nr.: 1496553-00-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Publications (4)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CLDN18.2

In Vitro

Zolbetuximab (0-100 μg/mL) binds to CLDN18.2⁺ PC cells, and induces antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Zolbetuximab (200 μg, i.v.) alone and in combination with Gemcitabine (HY-17026) (50 mg/kg, i.p.) exhibits antitumor activity in mouse BxPC-3-CLDN18.2 xenograft models^[2].
Zolbetuximab (5.7 mg/kg, i.p., three times per week for five weeks) inhibits tumor growth in SNU-620 cells xenograft model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

mouse BxPC-3-CLDN18.2, MIA PaCa-2-CLDN18.2 xenograft model^[2]
Dosage:

200 μg alone or with 50 mg/kg Gemcitabine
Administration:

i.v.; i.p. (Gemcitabine)
Result:

Inhibited tumor growth in two models, and prevented lung metastasis formation.
Prolonged survival time, and lowered fractions of CLDN18.2+ cells in MIA PaCa-2-CLDN18.2 xenograft.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

51208 [NCBI]

Accession

P56856

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, HY-P78368) can bind Zolbetuximab. The EC₅₀ for this effect is 6.588 ng/mL.

Chemical Information

CAS. Nr. 1496553-00-4
Appearance Liquid
Molecular Weight 147.09 kDa
Color Colorless to light yellow
SMILES

[Zolbetuximab]
Synonyms

IMAB362; Claudiximab; GC-182
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All Bio/Physico-chemical AssayCell Proliferation/Viability Assay

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Journal Impact Factor

Cell Commun Signal

Claudin-18.2 mediated interaction of gastric Cancer cells and Cancer-associated fibroblasts drives tumor progression. [Abstract]

2024 Jan 10;22(1):27. PMID: 38200591
Cell Rep

Integrative genomic identification of therapeutic targets for pancreatic cancer. [Abstract]

2025 Aug 21;44(9):116191. PMID: 40848256

Zolbetuximab purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Aug 21;44(9):116191. [Abstract]

Zolbetuximab (0.01-100 nM). Dose-response curves of PDAC organoids in cell surface target-specific cytoablation assay. Data are representative of three biological replicates and are shown as mean ± SD.
Mol Cancer Ther

Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody-Drug Conjugate for Treatment of CLDN18.2-Positive Cancers. [Abstract]

2023 Dec 1;22(12):1365-1375. PMID: 37788341
Heliyon

A novel highly sensitive inner filter effect-based fluorescence immunoassay with quantum dots for bioanalysis of zolbetuximab, a monoclonal antibody used for immunotherapy of gastric and gastroesophageal junction adenocarcinoma. [Abstract]

2024 Jul 14;10(14):e34611. PMID: 39114008

Zolbetuximab purchased from MedChemExpress. Usage Cited in: Heliyon. 2024 Jul 14;10(14):e34611. [Abstract]

The titration of varying concentrations of CLDN 18.2 protein versus a fixed high concentration of Zolbetuximab (ZOL, 2 μg/mL).

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Kyuno D, et, al. Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials. Tissue Barriers. 2022 Jan 2;10(1):1967080. [Content Brief]

[2]. Türeci Ӧ, et al. Characterization of zolbetuximab in pancreatic cancer models. Oncoimmunology. 2018 Nov 10;8(1):e1523096. [Content Brief]

[3]. Zhong W, et al. Development of a Humanized VHH Based Recombinant Antibody Targeting Claudin 18.2 Positive Cancers. Front Immunol. 2022 Jun 28;13:885424. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Zolbetuximab

4 Cited Publications

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100 mg

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Publications (4)
Reinheit & Dokumentation
Verweise

1/16

Human IgG1 kappa
1/16

Immobilized Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, HY-P78368) can bind Zolbetuximab. The EC₅₀ for this effect is 6.588 ng/mL.
1/16

Zolbetuximab purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Aug 21;44(9):116191. [Abstract]

Customer Validation
Zolbetuximab (0.01-100 nM). Dose-response curves of PDAC organoids in cell surface target-specific cytoablation assay. Data are representative of three biological replicates and are shown as mean ± SD.
1/16

Zolbetuximab purchased from MedChemExpress. Usage Cited in: Heliyon. 2024 Jul 14;10(14):e34611. [Abstract]

Customer Validation
The titration of varying concentrations of CLDN 18.2 protein versus a fixed high concentration of Zolbetuximab (ZOL, 2 μg/mL).
1/16

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Zolbetuximab

Publications Citing Use of MedChemExpress (MCE) Zolbetuximab