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Cat. No.: HY-112298

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DS88790512

DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC₅₀ of 11 nM.

For research use only. We do not sell to patients.

CAS No.: 2231089-95-3
Formula: C₂₂H₂₉N₃O₂
Molecular Weight:367.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

DS88790512 Chemical Structure

CAS No.: 2231089-95-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC₅₀ of 11 nM.

IC₅₀ & Target

IC50: 11 nM (TRPC6)^[1]

All TRP Channel Isoforms :

Chemical Information

CAS No. 2231089-95-3
Molecular Weight 367.48
Formula C₂₂H₂₉N₃O₂
SMILES

C[C@@]12[C@@](C[C@@H](N3C[C@H](N)CCC3)[C@@H]2OC4=CC=C(C#N)C=C4)([H])CC(CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Motoyama K, et al. Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6). Bioorg Med Chem Lett. 2018 Jul 1;28(12):2222-2227. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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DS88790512

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DS88790512 Related Classifications

HY-112298 Related Classifications