CD180 - CD180 molecule Gene

Also Known as LY64; Ly78; RP105

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4064

About CD180

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:67,179,613-67,196,799 (from NCBI)

This gene has 2 transcripts (splice variants), 128 orthologues and 22 paralogues. Biased expression in lymph node (RPKM 23.1), spleen (RPKM 12.8) and 10 other tissues.

Summary

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

CD180 Products (1)

mRNA Protein Name
NM_005582.3 NP_005573.2 CD180 antigen precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21857663 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
10880523 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD180 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (78 - 135)

LRR_8

LRR_8: Leucine rich repeat (345 - 407)

LRR_8

LRR_8: Leucine rich repeat (420 - 481)

LRR_8

LRR_8: Leucine rich repeat (497 - 544)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
Protein Preferred Names Protein Names

CD180 antigen

  • lymphocyte antigen 64

CD180 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD180 Q99467 LY86 Homo sapiens O95711
Pull Down
21857663
Intra
CD180 Q99467 LY86 Homo sapiens O95711
GMS
21857663
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD180 Proteins

Cat. No. Product Name Accession Purity
HY-P77181 RP105/CD180 Protein, Human (HEK293, His) Q99467/NP_005573.2 (W24-G626) ≥ 90%, as determined by reducing SDS-PAGE.

CD180 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84747 CD180 Antibody (YA4444) IHC-P, ICC/IF, FC, ELISA Human
HY-P84747A CD180 Antibody (YA4444)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Retinitis Pigmentosa 85

  • RP85

  • Retinitis Pigmentosa, Type 85
Ross River Fever

  • Ross River Virus Disease

  • Ross River Virus Infection
Retinitis Pigmentosa 74

  • RP74

  • Retinitis Pigmentosa, Type 74
Brachydactyly, Type C

  • Brachydactyly Type C

  • BDC

  • Brachydactyly Haws Type

  • Brachydactyly, Haws Type

  • Brachydactyly C
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02197 CD180 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19415 Cd180 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25907 Cd180 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991956 ABB071 Inhibitor / Unkown
HY-P992204 Anti-CD180 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CD180 VGNC VGNC:102176
Mus musculus CD180 MGD MGI:1194924
Macaca mulatta CD180 VGNC VGNC:70929
Bos taurus CD180 VGNC VGNC:52748
Canis familiaris CD180 VGNC VGNC:52119
Rattus norvegicus CD180 RGD RGD:1308170
Others CD180 NCBI