BEX1 - brain expressed X-linked 1 Gene

Also Known as BEX2; HBEX2; HGR74-h

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55859

About BEX1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:103,062,651-103,064,171 (from NCBI)

This gene has 1 transcript (splice variant), 145 orthologues and 3 paralogues. Biased expression in brain (RPKM 178.4), testis (RPKM 38.4) and 3 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

BEX1 Products (1)

mRNA Protein Name
NM_018476.4 NP_060946.3 protein BEX1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16314316 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16314316 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16314316 GOA
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16314316 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEX1 Protein Structure

BEX

BEX: Brain expressed X-linked like family (14 - 124)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

protein BEX1

  • brain-expressed X-linked protein 1

BEX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BEX1 Q9HBH7 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
BEX1 Q9HBH7 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 KLHL20 Homo sapiens Q9BS75
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 KLHL20 Homo sapiens Q9BS75
Y2H Array
32296183
Intra
BEX1 Q9HBH7 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
BEX1 Q9HBH7 OTP Homo sapiens Q5XKR4
Y2H Array
32296183
Intra
BEX1 Q9HBH7 OTP Homo sapiens Q5XKR4
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
BEX1 Q9HBH7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
BEX1 Q9HBH7 MAGEA2 Homo sapiens P43356
Y2H Array
32296183
Intra
BEX1 Q9HBH7 MAGEA2 Homo sapiens P43356
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
BEX1 Q9HBH7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
BEX1 Q9HBH7 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra
BEX1 Q9HBH7 CNOT2 Homo sapiens Q9NZN8
Validated Y2H
32296183
Intra
BEX1 Q9HBH7 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
BEX1 Q9HBH7 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
BEX1 Q9HBH7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
BEX1 Q9HBH7 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
BEX1 Q9HBH7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01480 BEX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01481 BEX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BEX1 RGD RGD:1564466
Others BEX1 NCBI