Luteolin 7-diglucuronide
Based on 1 publication(s) in Google Scholar
Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis.
For research use only. We do not sell to patients.
- Purity: 99.34%
- CAS No.: 96400-45-2
- Formula: C27H26O18
- Molecular Weight:638.48
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Luteolin 7-diglucuronide
MoreAll AMPK Isoforms
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Biological Activity
Luteolin 7-diglucuronide (5-50 µM, 24 h) inhibits the activity of protein tyrosine phosphatase 1B (PTP1B, IC50=2.10 µM), upregulates the phosphorylation of AMPK, thereby inhibiting the activation of hepatic stellate cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LX-2 and primary murine hepatic stellate cell
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Concentration:5-50 µM
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Incubation Time:24 h
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Result:Inhibited the expression of TGF-β1-induced HSCs activation markers such as Col-1, α-SMA and Fibronectin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Isoproterenol-administrated mouse models[2]
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Dosage:5-40 mg/kg
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Administration:ip, once daily for 5 days
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Result:Reduced myocardial necrosis, granulation tissue formation, and inflammatory cell infiltration.
Inhibited the expression of NADPH oxidase subunits (Cyba, Cybb, Ncf1, Ncf4 and Rac2) and ECM genes (such as Col1a1, Col1a2, Col3a1, Col12a1, Fbn1, elastin, and CTHRC1).
Chemical Information
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CAS No. 96400-45-2
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Appearance Solid
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Molecular Weight 638.48
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Formula C27H26O18
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Color Yellow to brown
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SMILES
O[C@@H]([C@@H]([C@@H](C(O)=O)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O2)O)O)O)[C@@H]1OC3=CC(O)=C4C(C=C(C5=CC=C(O)C(O)=C5)OC4=C3)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage-Mediated Metastatic Colonization. [Abstract]2025 Dec;12(46):e05291. PMID: 41216870
Solvent & Solubility
DMSO : ≥ 250 mg/mL (391.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Carnat A1, et al. Luteolin 7-diglucuronide, the major flavonoid compound from Aloysia triphylla and Verbena officinalis.Planta Med. 1995 Oct;61(5):490. [Content Brief]
[2]. Ning BB, et al., Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice. Acta Pharmacol Sin. 2017 Mar;38(3):331-341. [Content Brief]
[3]. Tang BX, et al., Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice. Acta Pharmacol Sin. 2025 Jan;46(1):122-133. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5662 mL | 7.8311 mL | 15.6622 mL | 39.1555 mL |
| 5 mM | 0.3132 mL | 1.5662 mL | 3.1324 mL | 7.8311 mL | |
| 10 mM | 0.1566 mL | 0.7831 mL | 1.5662 mL | 3.9155 mL | |
| 15 mM | 0.1044 mL | 0.5221 mL | 1.0441 mL | 2.6104 mL | |
| 20 mM | 0.0783 mL | 0.3916 mL | 0.7831 mL | 1.9578 mL | |
| 25 mM | 0.0626 mL | 0.3132 mL | 0.6265 mL | 1.5662 mL | |
| 30 mM | 0.0522 mL | 0.2610 mL | 0.5221 mL | 1.3052 mL | |
| 40 mM | 0.0392 mL | 0.1958 mL | 0.3916 mL | 0.9789 mL | |
| 50 mM | 0.0313 mL | 0.1566 mL | 0.3132 mL | 0.7831 mL | |
| 60 mM | 0.0261 mL | 0.1305 mL | 0.2610 mL | 0.6526 mL | |
| 80 mM | 0.0196 mL | 0.0979 mL | 0.1958 mL | 0.4894 mL | |
| 100 mM | 0.0157 mL | 0.0783 mL | 0.1566 mL | 0.3916 mL |
Luteolin 7-diglucuronide Related Classifications
HY-N7269 Related Classifications
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