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Cat. No.: HY-185561

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Misitatug blivedotin

(Synonyms: RC88)

Misitatug blivedotin (RC88) is an antibody-drug conjugate (ADC) targeting mesothelin (MSLN). Misitatug blivedotin binds to mesothelin and exhibits dose‐dependent antitumor activity. Misitatug blivedotin can be used for the research of ovarian cancer, non-squamous non-small-cell lung carcinoma, cervical cancer.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Misitatug blivedotin Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

RC88 effectively blocks CA125 from binding to MSLN^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL
Mice^[3]	0.75; 1.5; 3 mg/kg	i.v.	0.527 mL/h/kg
Cynomolgus Monkey^[3]	0.5; 1.5; 5 mg/kg	i.v.	0.556 mL/h/kg

In Vivo

Misitatug blivedotin (0.7-3 mg/kg; i.v.; Q1W × 1 or Q1W × 3) exhibits dose‐dependent antitumor activity in female Balb/c nude mice implanted subcutaneously with 3 million OVCAR3‐MSLN‐3# or H292‐MSLN‐9C8 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c nude mice (female; ages 4–5 weeks; implanted subcutaneously with 3 million OVCAR3‐MSLN‐3# or H292‐MSLN‐9C8 cells for a xenograft model)^[3]
Dosage:

0.7 mg/kg; 0.75 mg/kg; 1.5 mg/kg; 2.1 mg/kg; 3 mg/kg
Administration:

i.v.; Q1W × 1 or Q1W × 3
Result:

Had moderate activity at 0.75 mg/kg with single dosing, but tumor volume was less than the initial volume of tumors treated at 2.1 mg/kg until 11 days after dosing.
Significantly reduced the tumors 7 days after the first dosing at 1.5 and 3 mg/kg with multiple dosing.
Fully regressed tumors at 3 mg/kg for 10 days and at 1.5 mg/kg for 17 days, but the tumor continued to grow after three administrations at 0.75 mg/kg.

Chemical Information

SMILES

[Misitatug blivedotin]
Synonyms

RC88
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu YT, et al. The efficacy and safety of RC88 in patients with ovarian cancer, non-squamous-non-small-cell lung-carcinoma and cervical cancer: Results from a first-in-human phase 1/2 study. J Clin Oncol. 2024 May 29;42:5551.

[2]. Li Q, et al. Translation of the efficacy of antibody-drug conjugates from preclinical to clinical using a semimechanistic PK/PD model: A case study with RC88. Clin Transl Sci. 2023 Jul;16(7):1232-1242.

[3]. Wang l, et al. Abstract 2862: Anti MSLN ADC RC88 engages unique binding to target positive tumor cells with less interference from the soluble MSLN protein. Cancer Res.2015;85.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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