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Cat. No.: HY-107533

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T-98475

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.2 nM.

For research use only. We do not sell to patients.

CAS No.: 199119-18-1
Formula: C₃₇H₃₇F₂N₃O₄S
Molecular Weight:657.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

T-98475 Chemical Structure

CAS No.: 199119-18-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.2 nM^[1].

IC₅₀ & Target

IC₅₀: 0.2 nM (human LHRH receptor), 2 nM (monkey LHRH receptor), 4 nM (monkey anterior pituitaries), 60 nM (rat anterior pituitaries)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.2 nM Compound: 26d, T-98475	Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cells Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cells	[PMID: 16789738]
CHO	IC₅₀	0.6 nM Compound: 26d, T-98475	Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor	[PMID: 16789738]
CHO	IC₅₀	2 nM Compound: 26d, T-98475	Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cells Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cells	[PMID: 16789738]

Chemical Information

CAS No. 199119-18-1
Molecular Weight 657.77
Formula C₃₇H₃₇F₂N₃O₄S
SMILES

O=C(C1=CN(CC2=C(F)C=CC=C2F)C3=C(C1=O)C(CN(CC4=CC=CC=C4)C)=C(C5=CC=C(NC(C(C)C)=O)C=C5)S3)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3809-25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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