Anticancer agent 317
Anticancer agent 317, a Chidamide (HY-109015) derivative, is an apoptosis inducer. Anticancer agent 317 inhibits colony formation, migration, adhesion, invasion, tumor growth, and angiogenesis. Anticancer agent 317 can be used for the research of breast cancer.
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- CAS No.: 3117779-13-9
- Formule: C47H47ClFN9O3S
- Masse moléculaire:872.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
In Vitro
Anticancer agent 317 (Compound 6e) potently and selectively inhibits proliferation of MDA-MB-231 breast cancer cells with an IC50 of 0.10 μM[1].
Anticancer agent 317 (0.025-0.1 μM; 24 h) dose-dependently inhibits long-term colony formation of MDA-MB-231 breast cancer cells, with significant inhibition observed at concentrations as low as 0.025 μM[1].
Anticancer agent 317 (0.025-0.1 μM; 48 h) dose-dependently induces apoptosis in MDA-MB-231 breast cancer cells, with the highest level of apoptosis observed at 0.1 μM[1].
Anticancer agent 317 (0.01-0.04 μM; 24 h) dose-dependently inhibits adhesion of MDA-MB-231 breast cancer cells, with significant inhibition observed at concentrations as low as 0.01 μM[1].
Anticancer agent 317 (0.01-0.04 μM; 24-48 h) dose-dependently inhibits invasion of MDA-MB-231 breast cancer cells, with significant inhibition observed at concentrations as low as 0.01 μM[1].
Anticancer agent 317 (0.025-0.1 μM) dose-dependently inhibits angiogenesis and tumor growth in a chicken embryo CAM model of breast cancer, with the 0.1 μM dose reducing tumor weight to 8.33 mg and angiogenesis to 51.79% of control levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:0.025 μM; 0.05 μM; 0.1 μM
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Incubation Time:24 h
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Result:Dose-dependently reduced colony-forming ability of MDA-MB-231 cells, with colony formation rates of 66.17% at 0.025 μM, 50.00% at 0.05 μM, and 33.46% at 0.1 μM.
Showed stronger inhibitory activity than chidamide (86.07% colony formation rate) at 0.1 μM.
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Cell Line:MDA-MB-231
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Concentration:0.025 μM; 0.05 μM; 0.1 μM
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Incubation Time:48 h
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Result:Dose-dependently increased the proportion of Annexin V-positive apoptotic cells.
Markedly elevated the proportion of apoptotic cells (Annexin V-positive, PI-positive/negative) compared to untreated control at 0.1 μM, with 21.16% of cells in the early apoptotic quadrant and 29.33% in the late apoptotic quadrant.
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Cell Line:MDA-MB-231
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Concentration:0.01 μM; 0.02 μM; 0.04 μM
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Incubation Time:24 h; 48 h
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Result:Inhibited migration capacity at both 24 h and 48 h.
Reduced migration rates to 66.65% at 0.01 μM, 50.42% at 0.02 μM, and 30.99% at 0.04 μM after 48 h.
Showed stronger inhibitory activity than chidamide (51.69% migration rate at 48 h) at 0.04 μM.
- Human pluripotent stem cell endothelial-cell differentiation
- Vascular/Branching Fractal Analysis
- Annexin V plus membrane-impermeant dye apoptosis staining
- Cell migration
- Patient-Derived Orthotopic Xenograft (PDOX)
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Patient-Derived Xenograft (PDX)
- Endothelial Tube Formation Assay
- Apoptosis Solutions
- Cell invasion
- Soft Agar Colony Formation Assay
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Endothelial Cell Migration/Angiogenic Sprouting Assay
Chemical Information
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CAS No. 3117779-13-9
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Masse moléculaire 872.45
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Formule C47H47ClFN9O3S
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SMILES
CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCCNC5=CC(F)=CC=C5NC(C6=CC=C(C=C6)CNC(/C=C/C7=CC=CN=C7)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 317 Related Classifications
HY-183302 Related Classifications
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