BQ-610
BQ-610 is a selective antagonist of the endothelin A receptor (ETA receptor). BQ-610 specifically blocks the ETA receptor, competitively inhibiting the binding of endothelin-1 (ET-1) (a vasoconstrictive peptide) to the receptor, thereby blocking the effects of ET-1 such as vascular smooth muscle contraction, cell mitosis, and inhibition of hormone secretion. BQ-610 significantly alleviates cerebral vasospasm in rabbits. BQ-610 blocks the bronchial epithelial and pulmonary vascular cell proliferation caused by cigarette smoke in rat models. BQ-610 can delay the natural luteal regression in the cow's uterus. BQ-610 can be used for research on vasospasm, abnormal cell proliferation, and reproductive endocrine disorders.
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- CAS No.: 141595-53-1
- Formule: C36H44N6O6
- Masse moléculaire:656.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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ETA |
Chemical Information
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CAS No. 141595-53-1
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Masse moléculaire 656.77
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Formule C36H44N6O6
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SMILES
O=C(O)[C@@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3=CN(C=O)C4=C3C=CC=C4)NC([C@H](CC(C)C)NC(N5CCCCCC5)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Keator CS, et al. Intrauterine infusion of BQ-610, an endothelin type A receptor antagonist, delays luteolysis in dairy heifers. Domest Anim Endocrinol. 2008 May;34(4):411-8. [Content Brief]
[2]. Cirak B, et al. The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm. Clin Auton Res. 2004 Jun;14(3):197-201. [Content Brief]
[3]. Dadmanesh F, Wright JL. Endothelin-A receptor antagonist BQ-610 blocks cigarette smoke-induced mitogenesis in rat airways and vessels. Am J Physiol. 1997 Apr;272(4 Pt 1):L614-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BQ-610 Related Classifications
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