Brigatinib C
Based on 1 Customer Validation
Brigatinib C is a prodrug of ALK inhibitor, which can be used to syntheis PROTACs.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.72%
- CAS No.: 1197958-75-0
- Formule: C28H37ClN7O2P
- Masse moléculaire:570.07
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Activité biologique
|
EGFR |
FAK |
PYK2 |
PTK6 |
|
Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SR | IC50 |
6.8 nM
Compound: Brigatinib C
|
Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
|
[PMID: 34138566] |
| SR | IC50 |
6.8 nM
Compound: 3
|
Antiproliferative activity against human SR cells assessed as reduction in cell growth
Antiproliferative activity against human SR cells assessed as reduction in cell growth
|
[PMID: 32179332] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1197958-75-0
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Appearance Solid
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Masse moléculaire 570.07
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Formule C28H37ClN7O2P
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Color Off-white to light brown
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SMILES
COC1=CC(N2CCC(CC2)N3CCNCC3)=CC=C1NC4=NC=C(C(NC5=CC=CC=C5P(C)(C)=O)=N4)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (266 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)