Caprochlorone
Caprochlorone has antiviral activity against orthopoxvirus. Caprochlorone can inhibit cell penetration by virus, also delays release of newly formed virus from the cell. Caprochlorone decreases the titers of influenza virus in infected-mice lungs.
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- CAS No.: 13878-10-9
- Formule: C19H19ClO3
- Masse moléculaire:330.81
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
Orthopoxvirus, Influenza[2]
Chemical Information
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CAS No. 13878-10-9
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Masse moléculaire 330.81
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Formule C19H19ClO3
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SMILES
ClC(C=CC=C1)=C1CC(C(C)=O)(C2=CC=CC=C2)CCC(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureté et documentation
Références
[1]. Smee DF, Sidwell RW. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003;57(1-2):41-52. [Content Brief]
[2]. Stanfield FJ, Haff RF, Stewart RC. The antiviral activity of caprochlorone. Proc Soc Exp Biol Med. 1967;125(1):297-303. [Content Brief]
[3]. LIU OC, et al. Studies on the chemotherapy of viral infections. II. The effect of caprochlorone on influenza virus infections in mice. J Immunol. 1957;78(3):222-227. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Caprochlorone Related Classifications
HY-147013 Related Classifications
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