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Coltuximab

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Coltuximab is a CHO-expressed humanized antibody that targets CD19. Coltuximab is composed of huIgG1 heavy chains and huκ light chains, with a molecular weight (MW) of 144.70 kDa. The isotype control for Coltuximab can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

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  • Pureté: 98.43%
  • Masse moléculaire:144.70 kDa
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  • Experimental Validation Results for Coltuximab
  • Experimental Validation Results for Coltuximab
  • Coltuximab Chemical Structure
    Coltuximab Chemical Structure
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  • 1/16

    Immobilized Human CD19 (20-291) Protein can bind Coltuximab. The EC50 for this effect is 15.39 ng/mL.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD19 (red) with Coltuximab (HY-P990571). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Coltuximab Chemical Structure
    1/16
  • Coltuximab
  • Immobilized Human CD19 (20-291) Protein can bind Coltuximab. The EC50 for this effect is 15.39 ng/mL.
  • Flow Cytometry analysis of Raji cells labelling CD19 (red) with Coltuximab (HY-P990571). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).