Dracoflavan A
Dracoflavan A is a ring-opened triflavonoid compound found in the resin "dragon's blood", possessing antioxidant and anti-inflammatory activities, and it modulates oxidative stress and inflammatory signaling pathways. Dracoflavan A is used in research related to oxidative stress and inflammation.
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- CAS No.: 132185-42-3
- Formule: C49H46O10
- Masse moléculaire:794.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Dracoflavan A (compound 5) undergoes acetylation; 30 mg of the sample is dissolved in dry pyridine (0.3 mL), Ac2O (0.5 mL) is added, and the reaction proceeds for 30 min. Reaction with Ac2O in the pyridine system affords its triacetate derivative, confirming that the parent molecule contains three phenolic hydroxyl groups[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 132185-42-3
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Masse moléculaire 794.88
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Formule C49H46O10
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SMILES
O=C(C1=CC=CC=C1)OC(C=C(C(C)=C2OC)O)=C2CC(C3=C4C(CC[C@@H](C5=CC=CC=C5)O4)=C(C=C3O)OC)C6=C7C(CC[C@@H](C8=CC=CC=C8)O7)=C(C=C6O)OC
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dracoflavan A Related Classifications
HY-N21584 Related Classifications
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