Ephb4 - Eph receptor B4 Gene

Also Known as Htk; MDK2; Myk1; Tyro11; b2b2412Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13846

Summary

Predicted to enable transmembrane-ephrin receptor activity. Involved in angiogenesis; Ephrin Receptor signaling pathway; and heart morphogenesis. Acts upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EphB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Apr 2022]

Ephb4 Products (2)

mRNA Protein Name
NM_001159571.1 NP_001153043.1 ephrin type-B receptor 4 isoform a precursor
NM_010144.6 NP_034274.4 ephrin type-B receptor 4 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12971893 MGI
Biological Process GO Annotation Evidence Références Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
10518221 MGI
involved in ephrin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10518221 MGI
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
10518221 MGI
acts upstream of or within positive regulation of T cell costimulation IGI
IGI: Inferred from genetic interaction
15599401 MGI
acts upstream of or within positive regulation of aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
18952909 MGI
acts upstream of or within venous blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
18952909 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-B receptor 4

  • developmental kinase 2

  • hepatoma transmembrane kinase

  • mDK-2

  • tyrosine kinase MYK-1

Recombinant Ephb4 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P73004 EphB4 Protein, Mouse (HEK293, Fc) P54761 (L16-A539) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73005 EphB4 Protein, Mouse (HEK293, His) P54761 (L16-A539) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-16265 JI-101 Inhibitor 98.99% Phase 2

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-13258A NVP-BHG712 Inhibitor 99.71% Unkown
HY-13258 NVP-BHG712 isomer 99.32% Unkown
HY-136895 AZ12672857 Inhibitor 98.01% Unkown
HY-179572 STA-013 99.18% Unkown
HY-RS04436 EPHB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-15268 PP487 Inhibitor / Unkown
HY-155684 SA-PA Inhibitor / Unkown
HY-155685 SA-VA / Unkown
HY-16265A JI-101 hydrochloride Inhibitor / Unkown
HY-185227 EphB4-IN-1 Inhibitor / Unkown
HY-N3634 Corylifol C / Unkown
HY-171217 TG-100435 Inhibitor / Unkown
HY-186005 EPHB4 modulator-1 / Unkown
HY-RS17762 Ephb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24229 Ephb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ephb4 NCBI NCBI:2050