CTF1 - cardiotrophin 1 Gene

Also Known as CT1; CT-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1489

About CTF1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,895,846-30,903,560 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 1 paralogue. Broad expression in ovary (RPKM 6.4), heart (RPKM 3.8) and 20 other tissues.

Summary

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

CTF1 Products (2)

mRNA Protein Name
NM_001142544.3 NP_001136016.1 cardiotrophin-1 isoform 2
NM_001330.5 NP_001321.1 cardiotrophin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
21912637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cardiotrophin-1

  • cardiophin 1

Recombinant CTF1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P7149 Cardiotrophin-1/CTF1 Protein, Human (CHO) Q16619-1 (S2-A201) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7739 Cardiotrophin-1/CTF1 Protein, Human (His) Q16619-1 (M1-A201) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72870 Cardiotrophin-1/CTF1 Protein, Human (HEK293) Q16619-1 (S2-A201) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P72871 Cardiotrophin-1/CTF1 Protein, Human (HEK293, Fc) Q16619-1 (S2-A201) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Heart Valve Disease

  • Heart Valve Diseases

  • Valvular Heart Disease

  • Valvular Heart Diseases

  • Heart Valve Prolapse
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Motor Neuron Disease

  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Hypertensive Heart Disease
Crisponi/Cold-Induced Sweating Syndrome 2

  • Cold-Induced Sweating Syndrome 2

  • CISS2

  • Sweating Syndrome, Cold-Induced, Type 2
Cold-Induced Sweating Syndrome

  • Crisponi Syndrome

  • Sohar-Crisponi Syndrome

  • Ciss

  • Cntf Receptor-Related Disorders

  • Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

  • Sweating Syndrome, Cold-Induced
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-123761 L505-yne Inhibitor / Unkown
HY-RS03295 CTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17741 Ctf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24207 Ctf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CTF1 VGNC VGNC:99505
Bos taurus CTF1 VGNC VGNC:27793
Rattus norvegicus CTF1 RGD RGD:2442
Mus musculus CTF1 MGD MGI:105115
Canis familiaris CTF1 VGNC VGNC:54015
Others CTF1 NCBI