MAD2L1 - mitotic arrest deficient 2 like 1 Gene

Also Known as MAD2; HSMAD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4085

About MAD2L1

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:120,055,623-120,066,848 (from NCBI)

This gene has 5 transcripts (splice variants), 229 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 15.9), lymph node (RPKM 15.1) and 23 other tissues.

Summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

MAD2L1 Products (1)

mRNA	Protein	Name
NM_002358.4	NP_002349.1	mitotic spindle assembly checkpoint protein MAD2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16525508	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10200259	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	18022367	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in establishment of centrosome localization	IMP IMP: Inferred from mutant phenotype	23509069	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	23509069	GOA
involved in mitotic spindle assembly checkpoint signaling	IDA IDA: Inferred from direct assay	18981471	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20870947	GOA
acts upstream of or within negative regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21274008	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	11459825	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11459825	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IDA IDA: Inferred from direct assay	8824189	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	20870947	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	18981471	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	17363900	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	8824189	GOA
part of mitotic checkpoint complex	IPI IPI: Inferred from physical interaction	27509861	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	20133940	GOA
part of mitotic spindle assembly checkpoint MAD1-MAD2 complex	IPI IPI: Inferred from physical interaction	12006501	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	18981471	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18981471	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8824189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAD2L1 Protein Structure

HORMA

0
100
205 a.a.

Protein Preferred Names	Protein Names
mitotic spindle assembly checkpoint protein MAD2A	MAD2 (mitotic arrest deficient, yeast, homolog)-like 1

MAD2L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MAD2L1	Q13257	BUB1B	Homo sapiens	O60566	Anti Bait CoIP	21772247
Intra	MAD2L1	Q13257	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	33961781
Intra	MAD2L1	Q13257	DEPDC5	Homo sapiens	O75140-2	Y2H Array	32296183
Intra	MAD2L1	Q13257	DEPDC5	Homo sapiens	O75140-2	Y2H Prey Pooling	32296183
Intra	MAD2L1	Q13257	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	17443180
Intra	MAD2L1	Q13257	CDC20	Homo sapiens	Q12834	ITC	18318601
Intra	MAD2L1	Q13257	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	17443186
Intra	MAD2L1	Q13257	CDC20	Homo sapiens	Q12834	Solid Phase Assay	19143472
Intra	MAD2L1	Q13257	CDC20	Homo sapiens	Q12834	Pull Down	16525508
Intra	MAD2L1	Q13257	EPM2AIP1	Homo sapiens	Q7L775	Y2H Prey Pooling	32296183
Intra	MAD2L1	Q13257	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	MAD2L1	Q13257	EPM2AIP1	Homo sapiens	Q7L775	Y2H Array	32296183
Intra	MAD2L1	Q13257	EPM2AIP1	Homo sapiens	Q7L775	Anti Tag CoIP	33961781
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Y2H Array	32296183
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Anti Bait CoIP	21772247
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Y2H Prey Pooling	32296183
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Anti Tag CoIP	26496610
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Y2H Prey Pooling	25416956
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Validated Y2H	32296183
Intra	MAD2L1	Q13257	MAD2L1BP	Homo sapiens	Q15013	Anti Tag CoIP	33961781
Intra	MAD2L1	Q13257	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	MAD2L1	Q13257	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	MAD2L1	Q13257	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	MAD2L1	Q13257	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	25416956
Intra	MAD2L1	Q13257	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Pooling	16189514
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Anti Tag CoIP	26496610
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Anti Tag CoIP	21041666
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	18692475
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Pooling	18692475
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	IF	21772247
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Pull Down	21041666
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Pooling	16189514
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	Anti Bait CoIP	21772247
Intra	MAD2L1	Q13257	MAD1L1	Homo sapiens	Q9Y6D9	NMR	21041666
Intra	MAD2L1	Q13257	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	MAD2L1	Q13257	KEAP1	Homo sapiens	Q14145	Validated Y2H	25416956
Intra	MAD2L1	Q13257	KEAP1	Homo sapiens	Q14145	Validated Y2H	32296183
Intra	MAD2L1	Q13257	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	25416956
Intra	MAD2L1	Q13257	ADAM17	Homo sapiens	P78536	Y2H	10527948
Intra	MAD2L1	Q13257	ADAM17	Homo sapiens	P78536	Pull Down	10527948
Intra	MAD2L1	Q13257	ADAM17	Homo sapiens	P78536	CoIP	10527948
Intra	MAD2L1	Q13257	SGO2	Homo sapiens	Q562F6	Anti Tag CoIP	21666598
Intra	MAD2L1	Q13257	SGO2	Homo sapiens	Q562F6	Anti Tag CoIP	33961781
Intra	MAD2L1	Q13257	CDC27	Homo sapiens	P30260	Anti Bait CoIP	21772247
Intra	MAD2L1	Q13257	CDC27	Homo sapiens	P30260	Anti Tag CoIP	33961781
Intra	MAD2L1	Q13257	CDC27	Homo sapiens	P30260	Anti Tag CoIP	26496610
Intra	MAD2L1	Q13257	INSR	Homo sapiens	P06213-2	Y2H Prey Pooling	32296183
Intra	MAD2L1	Q13257	INSR	Homo sapiens	P06213-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAD2L1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71540	MAD2L1 Protein, Human (His-SUMO)	Q13257-1 (A2-D205)	≥ 90%, as determined by reducing SDS-PAGE.

MAD2L1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81947	MAD2L1 Antibody (YA1692)	WB	Human

Related Diseases

Diseases	Alias
Mosaic Variegated Aneuploidy Syndrome 1	Mva Syndrome MVA1 Mosaic Variegated Aneuploidy Syndrome, Type 1 Mosaic Variegated Aneuploidy Syndrome Congenital Chromosomal Disease
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS07949	MAD2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07950	MAD2L1BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20566	Mad2l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27075	Mad2l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAD2L1	RGD	RGD:1310889
Felis catus	MAD2L1	VGNC	VGNC:68125
Mus musculus	MAD2L1	MGD	MGI:1860374
Others	MAD2L1	NCBI