2. Gene
  3. MAD2L1BP - MAD2L1 binding protein Gene

MAD2L1BP - MAD2L1 binding protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CMT2

Gene ID: 9587 | Gene type: protein coding

About MAD2L1BP

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,629,540-43,640,941 (from NCBI)

This gene has 3 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in bone marrow (RPKM 14.5), duodenum (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

MAD2L1BP Products(2)

mRNA Protein Name
NM_001003690.2 NP_001003690.1 MAD2L1-binding protein isoform 1
NM_014628.3 NP_055443.1 MAD2L1-binding protein isoform 2

MAD2L1BP Protein Structure

p31comet

p31comet: Mad1 and Cdc20-bound-Mad2 binding (10 - 274)

  • 0
  • 100
  • 200
  • 274 a.a.
Protein Preferred Names Protein Names

MAD2L1-binding protein

caught by MAD2 protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07950 MAD2L1BP Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAD2L1BP MGD MGI:1913841
Bos taurus MAD2L1BP VGNC VGNC:31131
Rattus norvegicus MAD2L1BP RGD RGD:1309175
Canis familiaris MAD2L1BP VGNC VGNC:42915
Macaca mulatta MAD2L1BP VGNC VGNC:74325
Felis catus MAD2L1BP VGNC VGNC:63360