BAG6 - BAG cochaperone 6 Gene

Also Known as G3; BAT3; BAG-6; D6S52E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7917

About BAG6

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,639,028-31,652,661 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele and 242 orthologues. Broad expression in testis (RPKM 77.2), spleen (RPKM 25.1) and 25 other tissues.

Summary

This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by Caspase 3 and is implicated in the control of Apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG6 Products (59)

mRNA Protein Name
NM_001098534.2 NP_001092004.1 large proline-rich protein BAG6 isoform 2
NM_001199697.2 NP_001186626.1 large proline-rich protein BAG6 isoform 3
NM_001199698.2 NP_001186627.1 large proline-rich protein BAG6 isoform 4
NM_001387940.1 NP_001374869.1 large proline-rich protein BAG6 isoform 4
NM_001387942.1 NP_001374871.1 large proline-rich protein BAG6 isoform 22
NM_001387943.1 NP_001374872.1 large proline-rich protein BAG6 isoform 20
NM_001387944.1 NP_001374873.1 large proline-rich protein BAG6 isoform 21
NM_001387946.1 NP_001374875.1 large proline-rich protein BAG6 isoform 20
NM_001387949.1 NP_001374878.1 large proline-rich protein BAG6 isoform 4
NM_001387951.1 NP_001374880.1 large proline-rich protein BAG6 isoform 25
NM_001387954.1 NP_001374883.1 large proline-rich protein BAG6 isoform 12
NM_001387955.1 NP_001374884.1 large proline-rich protein BAG6 isoform 19
NM_001387956.1 NP_001374885.1 large proline-rich protein BAG6 isoform 4
NM_001387958.1 NP_001374887.1 large proline-rich protein BAG6 isoform 18
NM_001387961.1 NP_001374890.1 large proline-rich protein BAG6 isoform 2
NM_001387963.1 NP_001374892.1 large proline-rich protein BAG6 isoform 15
NM_001387964.1 NP_001374893.1 large proline-rich protein BAG6 isoform 14
NM_001387965.1 NP_001374894.1 large proline-rich protein BAG6 isoform 12
NM_001387982.1 NP_001374911.1 large proline-rich protein BAG6 isoform 14
NM_001387983.1 NP_001374912.1 large proline-rich protein BAG6 isoform 13
NM_001387984.1 NP_001374913.1 large proline-rich protein BAG6 isoform 12
NM_001387985.1 NP_001374914.1 large proline-rich protein BAG6 isoform 11
NM_001387986.1 NP_001374915.1 large proline-rich protein BAG6 isoform 2
NM_001387987.1 NP_001374916.1 large proline-rich protein BAG6 isoform 10
NM_001387988.1 NP_001374917.1 large proline-rich protein BAG6 isoform 6
NM_001387989.1 NP_001374918.1 large proline-rich protein BAG6 isoform 5
NM_001387990.1 NP_001374919.1 large proline-rich protein BAG6 isoform 10
NM_001387991.1 NP_001374920.1 large proline-rich protein BAG6 isoform 7
NM_001387992.1 NP_001374921.1 large proline-rich protein BAG6 isoform 7
NM_001387993.1 NP_001374922.1 large proline-rich protein BAG6 isoform 6
NM_001387994.1 NP_001374923.1 large proline-rich protein BAG6 isoform 5
NM_001387995.1 NP_001374924.1 large proline-rich protein BAG6 isoform 6
NM_001387996.1 NP_001374925.1 large proline-rich protein BAG6 isoform 5
NM_001387997.1 NP_001374926.1 large proline-rich protein BAG6 isoform 21
NM_001387998.1 NP_001374927.1 large proline-rich protein BAG6 isoform 19
NM_001387999.1 NP_001374928.1 large proline-rich protein BAG6 isoform 4
NM_001388000.1 NP_001374929.1 large proline-rich protein BAG6 isoform 4
NM_001388001.1 NP_001374930.1 large proline-rich protein BAG6 isoform 4
NM_001388002.1 NP_001374931.1 large proline-rich protein BAG6 isoform 17
NM_001388003.1 NP_001374932.1 large proline-rich protein BAG6 isoform 16
NM_001388004.1 NP_001374933.1 large proline-rich protein BAG6 isoform 14
NM_001388005.1 NP_001374934.1 large proline-rich protein BAG6 isoform 13
NM_001388006.1 NP_001374935.1 large proline-rich protein BAG6 isoform 12
NM_001388007.1 NP_001374936.1 large proline-rich protein BAG6 isoform 10
NM_001388008.1 NP_001374937.1 large proline-rich protein BAG6 isoform 9
NM_001388009.1 NP_001374938.1 large proline-rich protein BAG6 isoform 8
NM_001388010.1 NP_001374939.1 large proline-rich protein BAG6 isoform 6
NM_001388011.1 NP_001374940.1 large proline-rich protein BAG6 isoform 5
NM_001388012.1 NP_001374941.1 large proline-rich protein BAG6 isoform 23
NM_001388013.1 NP_001374942.1 large proline-rich protein BAG6 isoform 24
NM_001388014.1 NP_001374943.1 large proline-rich protein BAG6 isoform 4
NM_001388015.1 NP_001374944.1 large proline-rich protein BAG6 isoform 2
NM_001388016.1 NP_001374945.1 large proline-rich protein BAG6 isoform 13
NM_001388017.1 NP_001374946.1 large proline-rich protein BAG6 isoform 2
NM_001388018.1 NP_001374947.1 large proline-rich protein BAG6 isoform 2
NM_001388019.1 NP_001374948.1 large proline-rich protein BAG6 isoform 6
NM_001388020.1 NP_001374949.1 large proline-rich protein BAG6 isoform 5
NM_080702.3 NP_542433.1 large proline-rich protein BAG6 isoform 2
NM_080703.3 NP_542434.1 large proline-rich protein BAG6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
24133212 GOA
enables misfolded protein binding IDA
IDA: Inferred from direct assay
21636303 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
25713138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
18852879 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
20676083 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
18852879 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21636303 GOA
enables ubiquitin-specific protease binding IPI
IPI: Inferred from physical interaction
24424410 GOA
Biological Process GO Annotation Evidence Références Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
23129660 GOA
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
26565908 GOA
involved in NK T cell activation IDA
IDA: Inferred from direct assay
18852879 GOA
involved in apoptotic process IDA
IDA: Inferred from direct assay
14960581 GOA
involved in endoplasmic reticulum stress-induced pre-emptive quality control IMP
IMP: Inferred from mutant phenotype
26565908 GOA
involved in immune response-activating cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
18852879 GOA
involved in internal peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
17403783 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17403783 GOA
involved in maintenance of unfolded protein IMP
IMP: Inferred from mutant phenotype
21636303 GOA
involved in natural killer cell activation IDA
IDA: Inferred from direct assay
18852879 GOA
involved in positive regulation of ERAD pathway IMP
IMP: Inferred from mutant phenotype
24424410 GOA
involved in post-translational protein targeting to endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25535373 GOA
involved in proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
26565908 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
21636303 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
20676083 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20676083 GOA
Cellular Component GO Annotation Evidence Références Source
part of BAT3 complex IDA
IDA: Inferred from direct assay
20676083 GOA
part of BAT3 complex IPI
IPI: Inferred from physical interaction
25535373 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21636303 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17403783 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
18852879 GOA
located in membrane IDA
IDA: Inferred from direct assay
23246001 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14960581 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG6 Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (22 - 87)

DUF3538

DUF3538: Domain of unknown function (DUF3538) (270 - 386)

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  • 1126 a.a.
Protein Preferred Names Protein Names

large proline-rich protein BAG6

  • BAG family molecular chaperone regulator 6

BAG6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
BAG6 P46379 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Cross
BAG6 P46379 sars8a Human SARS coronavirus Q19QW2
Lumier
22046132
Cross
BAG6 P46379 sars8a Human SARS coronavirus Q19QW2
Y2H Pooling
22046132
Intra
BAG6 P46379 SGTA Homo sapiens O43765
Y2H
14667819
Intra
BAG6 P46379 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra
BAG6 P46379 RNF126 Homo sapiens Q9BV68
Anti Tag CoIP
35271311
Intra
BAG6 P46379 RNF126 Homo sapiens Q9BV68
Y2H Array
31515488
Intra
BAG6 P46379 RNF126 Homo sapiens Q9BV68
Y2H
14667819
Intra
BAG6 P46379 RNF126 Homo sapiens Q9BV68
Validated Y2H
25416956
Intra
BAG6 P46379 RNF126 Homo sapiens Q9BV68
Anti Tag CoIP
26496610
Intra
BAG6 P46379 RNF126 Homo sapiens Q9BV68
Y2H Prey Pooling
25416956
Intra
BAG6 P46379 EFEMP1 Homo sapiens Q12805
Y2H Prey Pooling
25416956
Intra
BAG6 P46379 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
25416956
Intra
BAG6 P46379 KLHL12 Homo sapiens Q53G59
Validated Y2H
25416956
Intra
BAG6 P46379 KLHL12 Homo sapiens Q53G59
Y2H Pooling
16189514
Intra
BAG6 P46379 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
25416956
Intra
BAG6 P46379 MAVS Homo sapiens Q7Z434
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

BAG6 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82506 BAT3 Antibody (YA2251) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P82506A BAT3 Antibody (YA2251)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01347 BAG6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BAG6 MGD MGI:1919439
Macaca mulatta BAG6 VGNC VGNC:81044
Bos taurus BAG6 VGNC VGNC:26410
Rattus norvegicus BAG6 RGD RGD:71064
Canis familiaris BAG6 VGNC VGNC:38368
Felis catus BAG6 VGNC VGNC:60069
Others BAG6 NCBI