WDR59 - WD repeat domain 59 Gene

Also Known as CDW12; FP977; p90-120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79726

About WDR59

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:74,871,362-74,985,123 (from NCBI)

This gene has 23 transcripts (splice variants), 199 orthologues and 9 paralogues. Ubiquitous expression in skin (RPKM 11.4), thyroid (RPKM 10.4) and 25 other tissues.

Summary

Involved in cellular response to amino acid starvation and positive regulation of TOR signaling. Located in lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

WDR59 Products (3)

mRNA Protein Name
NM_001324171.2 NP_001311100.1 GATOR complex protein WDR59 isoform 2
NM_001324172.2 NP_001311101.1 GATOR complex protein WDR59 isoform 3
NM_030581.4 NP_085058.3 GATOR complex protein WDR59 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25263562 GOA
Biological Process GO Annotation Evidence Références Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
23723238 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
35831510 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35831510 GOA
Cellular Component GO Annotation Evidence Références Source
part of GATOR2 complex IDA
IDA: Inferred from direct assay
35831510 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
28199306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR59 Protein Structure

WD40

WD40: WD domain, G-beta repeat (96 - 134)

WD40

WD40: WD domain, G-beta repeat (187 - 220)

WD40

WD40: WD domain, G-beta repeat (273 - 314)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 974 a.a.
Protein Preferred Names Protein Names

GATOR complex protein WDR59

  • CDw12 antigen

WDR59 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
WDR59 Q6PJI9 CASTOR1 Homo sapiens Q8WTX7
Anti Tag CoIP
26972053
Intra
WDR59 Q6PJI9 CASTOR2 Homo sapiens A6NHX0
Anti Tag CoIP
26972053
Intra
WDR59 Q6PJI9 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intermittent Explosive Disorder

  • Explosive Personality Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15788 WDR59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus WDR59 RGD RGD:1592213
Mus musculus WDR59 MGD MGI:2442115
Felis catus WDR59 VGNC VGNC:67041
Canis familiaris WDR59 VGNC VGNC:48376
Macaca mulatta WDR59 VGNC VGNC:79531
Bos taurus WDR59 VGNC VGNC:36907
Others WDR59 NCBI