Histargin
Histargin is a selective carboxypeptidase B inhibitor with an IC50 of 17 μg/mL and a Ki of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B.
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- CAS No.: 93361-66-1
- Formule: C14H25N7O4
- Masse moléculaire:355.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
carboxypeptidase B 17 μg/mL (IC50) |
carboxypeptidase B 30 μM (Ki) |
In Vitro
Histargin monohydrate (30 min) potently and competitively inhibits purified bovine carboxypeptidase B with an IC50 of 17 μg/mL and a Ki of 3.2 × 10-5 M, and this inhibitory activity is dependent on metal chelation, being blocked by specific divalent metal cations[1].
Histargin does not inhibit purified carboxypeptidase A, aminopeptidase A (IC50 >100 μg/mL)[1].
Histargin lacks antimicrobial activity at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 93361-66-1
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Masse moléculaire 355.39
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Formule C14H25N7O4
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SMILES
N=C(N)NCCC[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC1=CN=CN1
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Structure Classification
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Initial Source
Streptomyces roseoviridis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Histargin Related Classifications
HY-122369 Related Classifications
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