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Cat. No.: HY-122369

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Histargin

Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B.

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CAS No.: 93361-66-1
Formule: C₁₄H₂₅N₇O₄
Masse moléculaire:355.39

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Histargin Chemical Structure

CAS No.: 93361-66-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

carboxypeptidase B

17 μg/mL (IC₅₀)

carboxypeptidase B

30 μM (Ki)

In Vitro

Histargin monohydrate (30 min) potently and competitively inhibits purified bovine carboxypeptidase B with an IC₅₀ of 17 μg/mL and a K_i of 3.2 × 10^-5 M, and this inhibitory activity is dependent on metal chelation, being blocked by specific divalent metal cations^[1].
Histargin does not inhibit purified carboxypeptidase A, aminopeptidase A (IC50 >100 μg/mL)^[1].
Histargin lacks antimicrobial activity at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 93361-66-1
Masse moléculaire 355.39
Formule C₁₄H₂₅N₇O₄
SMILES

N=C(N)NCCC[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC1=CN=CN1
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Streptomyces roseoviridis
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. UMEZAWA H, et al. Histargin, a new inhibitor of carboxypeptidase B, produced by actinomycetes[J]. The Journal of Antibiotics, 1984, 37(9): 1088-1090.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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