Hydrostatin-TL1
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research.
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- CAS No.: 2243975-43-9
- Formule: C39H71N11O13S
- Masse moléculaire:934.11
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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JNK |
ERK |
p38 |
IL-8 |
Hydrostatin-TL1 (1-1000 nM, 18-20 h) inhibits TNF-α-induced L929 cells death in a concentration-dependent manner [1].
Hydrostatin-TL1 (0.2-1.6 μM) significantly inhibits the TNF-α-induced phosphorylation of p38, ERK, JNK, and IκB protein within the NF-κB and MAPKs signaling pathways in HEK-293 cells[1].
Hydrostatin-TL1 fails to inhibit the phosphorylation of IκB induced by IL-1β in HEK-293 cells[1].
Hydrostatin-TL1 (0.1-0.8 nM) dose-dependently reduces TNF-α-mediated mRNA expression of pro-inflammatory factors (IL-8, TNF-α, ICAM-1, and VCAM-1) in HEK-293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hydrostatin-TL1 (20-80 μg/kg, three times at 1, 3 and 5 h) dose-dependently reduces mortality in LPS (HY-D1056)-induced acute shock mice model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2243975-43-9
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Masse moléculaire 934.11
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Formule C39H71N11O13S
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Synonyms
H-TL1
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Sequence
Ala-Thr-Ser-Lys-Pro-Ser-Leu-Lys-Cys
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Sequence Shortening
ATSKPSLKC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydrostatin-TL1 Related Classifications
HY-P11214 Related Classifications
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