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Cat. No.: HY-182568

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Iocarmic acid

Iocarmic acid is a myelographic contrast agent. Iocarmic acid is used for lumbar nerve root angiography and ventriculography. Iocarmic acid induces arachnoiditis via lumbar subarachnoid injection. Iocarmic acid can be used for the research of arachnoiditis.

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CAS No.: 10397-75-8
Formule: C₂₄H₂₀I₆N₄O₈
Masse moléculaire:1253.86

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Iocarmic acid Chemical Structure

CAS No.: 10397-75-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
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Activité biologique

Description

In Vivo

Iocarmic acid (1.2 mL of 282 mg I/mL; intrathecal; single injection) induces severe arachnoiditis in macaque monkeys undergoing experimental myelography, with maximum myelographic scores and an average histologic score of 18, which is significantly higher than scores for comparator contrast media and controls^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Macaque monkeys (5-7 kg)^[1]
Dosage:

1.2 mL of 282 mg I/mL
Administration:

intrathecal; single injection
Result:

Induced a consistent myelographic arachnoiditis score of 36 (maximum possible score) across all 4 animals tested.
Produced an average histologic arachnoiditis score of 18, with individual scores ranging from 12 to 20.
Resulted in scores significantly higher than scores for iopamidol, metrizamide, and CSF controls (P < 0.05, Wilcoxon test).

Chemical Information

CAS No. 10397-75-8
Masse moléculaire 1253.86
Formule C₂₄H₂₀I₆N₄O₈
SMILES

O=C(C1=C(C(NC(CCCCC(NC2=C(I)C(C(NC)=O)=C(I)C(C(O)=O)=C2I)=O)=O)=C(C(C(NC)=O)=C1I)I)I)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Haughton VM, et al. Arachnoiditis from myelography with iopamidol, metrizamide, and iocarmate compared in the animal model. Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S267. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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