JWP24
JWP24 is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC50 of 200 nM against human MAGE-A4. JWP24 binds to intracellular targets while retaining binding activity, disrupts the interaction between MAGE-A4 and RAD18, and does not induce cytotoxicity at effective concentrations. JWP24 is applicable for cancer-related research.
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- Formule: C68H89FN12O12S2
- Masse moléculaire:1349.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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RAD18 |
JWP24 (0.005-80 μM; 1.5 h) potently disrupts the interaction between MAGE-A4 and RAD18 in HEK293 cells, with an IC50 of 0.5 μM, and exhibits no cytotoxicity at effective concentrations[1].
JWP24 (10 μM; 2 h) inhibits the interaction between MAGE-A4 and RAD18 in H1299 cell lysates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H1299 cells (transiently transfected with plasmids expressing Myc-RAD18 and HA-MAGE-A4)
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Concentration:10 μM
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Incubation Time:2 h
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Result:Bound to the conserved MHD of MAGE-A4 and effectively inhibit the MAGE-A4/RAD18 interaction.
Chemical Information
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Masse moléculaire 1349.64
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Formule C68H89FN12O12S2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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