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Cat. No.: HY-P992539

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LP-005

LP-005 is a bifunctional anti-C5 antibody fusion protein with pH-dependent C5 binding properties. LP-005 can simultaneously inhibit activation of the terminal complement pathway and the alternative pathway. LP-005 can be used for research on paroxysmal nocturnal hemoglobinuria (PNH).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LP-005 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Species Reactivity
- In Vitro
- In Vivo
- Target
- Conjugated
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Species Reactivity

Human

In Vitro

LP-005 binds human C5 with pH-dependent kinetics, with a K_D of 6.70 × 10^-10 M at pH 7.4 and 2.45 × 10^-9 M at pH 6.0^[1].
LP-005 inhibits antibody-sensitized sheep erythrocyte hemolysis in 1% NHS with an IC₅₀ of 0.41 nM^[1].
LP-005 (20% ABO-compatible serum; pH 7.3) inhibits AP-induced hemolysis of CD59-deficient PNH erythrocytes by > 70%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LP-005 (intravenous infusion) can elevate hemoglobin levels and reduce LDH^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Target

C5 & C3b

Conjugated

Unconjugated

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[LP-005]
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Cheng L, et al. A Novel pH Dependent C5 Monoclonal Antibody with Better Developability. Blood. 2020;136(Supplement 1):11-12.

[2]. He G, et al. LP-005, a bifunctional C5 antibody fusion protein, efficacy and safety in PNH patients with active hemolysis: Updated results from a Phase 2 study at 12/24 weeks. Blood. 2025;146(Supplement 1):983.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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