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Cat. No.: HY-130408

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m-PEG6-Amine

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m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Pureté: 98.0%
CAS No.: 184357-46-8
Formule: C₁₃H₂₉NO₆
Masse moléculaire:295.37

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4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

m-PEG6-Amine Chemical Structure

CAS No.: 184357-46-8

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Description

m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target^[1]^[2]

Cleavable Linker

PEGs

Voir tous les produits spécifiques à Isoform ADC Linkers :

Voir tous les produits spécifiques à Isoform PROTAC Linkers :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 184357-46-8
Appearance Liquid (Density: 1.036±0.06 g/cm³)
Masse moléculaire 295.37
Formule C₁₃H₂₉NO₆
Color Colorless to light yellow
SMILES

COCCOCCOCCOCCOCCOCCN
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Sep Purif Technol

2025 Dec 22.

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
SDS (477 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.

[2]. Austin G Wardrip, et al. Length-Independent Charge Transport in Chimeric Molecular Wires. Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14267-14271. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

m-PEG6-Amine

1 Cited Publications

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Chemical Information
Publications (1)
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m-PEG6-Amine

Publications Citing Use of MedChemExpress (MCE) m-PEG6-Amine

Voir tous les produits spécifiques à Isoform ADC Linkers

Voir tous les produits spécifiques à Isoform PROTAC Linkers

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m-PEG6-Amine Related Classifications

HY-130408 Related Classifications