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Cat. No.: HY-117668

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MDL 101146

MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K_i value of 25 nM. MDL 101146 can be used for the research of arthritis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 149859-17-6
Formule: C₂₉H₃₇F₅N₄O₆
Masse moléculaire:632.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MDL 101146 Chemical Structure

CAS No.: 149859-17-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)^[1]^[2]

In Vitro

MDL 101,146 inhibits human neutrophil elastase with a K_i value of 25 nM^[1].
MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a K_i value of 18 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats^[2]
Dosage:

200 mg/kg
Administration:

Oral, 200 mg/kg/day
Result:

Inhibited the severity of collagen-induced arthritis.
Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.

Chemical Information

CAS No. 149859-17-6
Masse moléculaire 632.62
Formule C₂₉H₃₇F₅N₄O₆
SMILES

O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl [Content Brief]

[2]. M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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