Mefruside
Based on 1 Customer Validation
Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension.
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- Pureté: 99.9%
- CAS No.: 7195-27-9
- Formule: C13H19ClN2O5S2
- Masse moléculaire:382.88
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Mefruside (0.3 mM; 50 min) shows 34% inhibition of urea synthesis in isolated perfused rat liver[1].
Mefruside (0.25, 0.5, 0.75, 1, 1.25 mM) inhibits urea synthesis in a concentration-dependent manner in isolated perfused rat liver[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat liver (from male Wistar rats of 120-220 g body weight; isolated perfused model)
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Concentration:0.3 mM
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Incubation Time:50 min
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Result:Exhibited inhibition rate of urea synthesis of 34%.
Chemical Information
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CAS No. 7195-27-9
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Appearance Solid
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Masse moléculaire 382.88
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Formule C13H19ClN2O5S2
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Color White to off-white
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SMILES
O=S(C1=CC=C(C(S(=O)(N)=O)=C1)Cl)(N(CC2(OCCC2)C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (269 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Häussinger D, et al. Liver carbonic anhydrase and urea synthesis. Hepatology. 1988 Mar-Apr;8(2):435. [Content Brief]
[2]. Brogden RN, et al. Mefruside: a preliminary report of its pharmacological properties and therapeutic efficacy in oedema and hypertension. Drugs. 1974;7(6):419-25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mefruside Related Classifications
HY-123179 Related Classifications
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