Menadiol (Standard)
Menadiol (Standard) (Dihydrovitamin K3 (Standard)) is the analytical standard of Menadiol (HY-W128525). This product is intended for research and analytical applications. Menadiol (Dihydrovitamin K3) is a menadione analog that acts as an electron donor. Menadiol transfers electrons to the heme bL of E. coli nitrate reductase A and, via heme bH, to the catalytic NarGH dimer. Menadiol drives ATP-dependent NAD⁺ reduction (reverse electron transport) in submitochondrial particles. Menadiol selectively inhibits the growth of lymphoid tumor cells. Menadiol enhances the growth-inhibitory effects of Mechlorethamine, Vincristine (HY-N0488A), and Dexamethasone (HY-14648) on tumor cells, converting a drug-resistant phenotype to a sensitive phenotype. Menadiol is used in research related to lymphoid tumors.
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- CAS No.: 481-85-6
- Formule: C11H10O2
- Masse moléculaire:174.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 481-85-6
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Masse moléculaire 174.20
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Formule C11H10O2
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SMILES
CC1=C(C2=CC=CC=C2C(=C1)O)O
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Synonyms
Dihydrovitamin K3 (Standard)
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Zhao Z, et al. Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study. Biochemistry. 2003 Dec 09;42(48):14225-33. [Content Brief]
[2]. Taggart WV, et al. Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles. Biochim Biophys Acta. 1972 Jun 23;267(3):439-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Menadiol (Standard) Related Classifications
HY-W128525R Related Classifications
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Keywords
- Menadiol (Standard)
- 481-85-6
- Dihydrovitamin K3 (Standard)
- Reference Standards
- Mitochondrial Metabolism
- Oxidative Phosphorylation
- mitochondrial respiratory chain
- NarGH dimer
- human lymphatic neoplasm cells
- heme b_L
- menadione semiquinone radical anion
- E. coli nitrate reductase A
- reversed electron flow
- heme b_H
- bovine heart submitochondrial particles
- menaquinol analogue
- Inhibitor
- inhibitor
- inhibit