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Cat. No.: HY-123693

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ML358

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC₅₀=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics.

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CAS No.: 1158607-44-3
Formule: C₂₁H₂₆Cl₃NO₂
Masse moléculaire:430.80

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

ML358 Chemical Structure

CAS No.: 1158607-44-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IC₅₀ & Target

IC50: 0.24 μM (SKN-1)^[1]

Chemical Information

CAS No. 1158607-44-3
Masse moléculaire 430.80
Formule C₂₁H₂₆Cl₃NO₂
SMILES

CCOC1=C(C(Cl)=CC(CNC2CCCC2)=C1)OCC3=CC=C(C=C3)Cl.[H]Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Hazard Mater

Isobavachalcone confers protection against Cryptococcus neoformans-induced ferroptosis in Caenorhabditis elegans via lifespan extension and GSH-GPX-1 axis modulation. [Abstract]

2025 Mar 18:492:137969. PMID: 40154123

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Peddibhotla, S, et al. Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. ACS Chemical Biology, 10(8), 1871–1879. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Pureté et documentation
Références

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ML358

Publications Citing Use of MedChemExpress (MCE) ML358